Natural Progesterone UK - Natpro UK
The Choice of the "informed woman"
(with thanks to Dr J.Lee MD)
This information will help you to be educated about the unwanted effects of low or no progesterone and too much estrogen (Estrogen Dominance) and the subsequent unpleasant symptoms associated with the Menopause, PMS, and the conditions of infertility & osteoporosis.
After the WHI trial was stopped it was widely reported that the patients receiving combined treatment with estrogen and progestin had a higher incidence of breast cancer than the group receiving estrogen alone, however, bioidentical progesterone was not used in this study. Bioidentical progesterone has been found not to increase the risk of breast cancer when used in combined hormone therapy with estrogens, while synthetic progestins did increase the risk (Fournier et al. 2005).
Bone loss, leading to reduced bone mineral density (BMD) and eventually osteoporosis, is the result when osteoclast-mediated bone resorption and osteoblast-mediated bone formation become unbalanced. In the normal state, the bone is in a state of homeostasis in which bone is formed at the same rate as it is resorbed (i.e., broken down to release calcium into the bloodstream, which is a mechanism for maintaining blood calcium levels) and this is referred to as “bone turnover”.
A number of hormonal changes occur as women enter menopause. The transition is characterized by erratic, but on average, higher than premenopausal estrogen levels, while progesterone levels steadily decline as the number of menstrual cycles without ovulation increases, and remain extremely low thereafter.
Progesterone is named because of its essential functions in maintaining conditions in the uterus that sustain pregnancy (pro-gestation). During the menstrual cycle, estrogen causes the uterine lining to proliferate in preparation for implantation of a fertilized egg, and it stimulates a number of physiological events designed to prepare the body for pregnancy, such as stimulation of protein and lipid synthesis and mitotic activity.
There is already significant evidence that progesterone (unlike synthetic progestins) has no adverse effects on cardiovascular risk factors. No change in any of the thrombotic or inflammatory markers studied was observed, despite significant symptomatic improvement compared to placebo, in 30 women receiving 20 mg/day progesterone cream for 4 weeks (Stephenson et al. 2004).
Can progesterone help recovery from Polycystic Ovarian Syndrome (PCOS)?
PCOS is a condition that is rising alarmingly all over the world.
It is the most prevalent reproductive problem in young girls and women, affecting up to 10% in the 15 to 50 age group. Although reaching almost 25% if women with mild cystic ovaries and ovaries damaged by the contraceptive pill are included.